American Association for Clinical Chemistry
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Is This A Straight Trait (AS) or Are We All Wet?

3/5/2013 9:32 AM | Comments (0) Recommend (248)

By William E. Winter, MD; Lindsay Bazydlo, PhD, and Neil S. Harris, MD
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​Challenge: The patient is a 16 month old male. How should the results of the following hemoglobin electrophoresis be interpreted?   By alkaline gel electrophoresis: 59.5%  hemoglobin A0.6%   hemoglobin F36.6%  hemoglobin S By cation-exchange HPLC BioRad D-10 (Extended Program): hemoglobin A2 ...(Read More)
Posted at 3/5/2013 9:32 AM | Tags: Case Study | Molecular Pathology and Genetics
Pharmacogenetics: Expectations vs. Reality

2/28/2012 8:28 AM | Comments (0) Recommend (878)

By Linnea M. Baudhuin, PhD, DABMG
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​Despite the many different clinical applications in the field of pharmacogenetics (PGx), the clinical uptake of pharmacogenetic testing has, for the most part, not yet met expectations. While not all potential PGx applications have robustly proven clinical utility, there are several tests which ha...(Read More)
Posted at 2/28/2012 8:28 AM | Tags: Instrumentation/Technology | Molecular Pathology and Genetics
If Not Hemophilia, What Is Causing This Bleeding Disorder?

9/20/2011 7:58 AM | Comments (1) Recommend (1,535)

By William Winter, MD
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A toddler has a history of severe bleeding with minor trauma. Child abuse was excluded by evaluation of the family. The initial evaluation includes normal PT, PTT, thrombin time, platelet count and PFA-100. What should you next consider and how can the diagnosis be made?   Response: Factor XIII de...(Read More)
Posted at 9/20/2011 7:58 AM | Tags: Case Study | Special Populations | Molecular Pathology and Genetics
Explosive Growth of Send Out Testing: Can We Curb the Monster?

1/18/2011 9:20 AM | Comments (6) Recommend (1,487)

By Patti Jones, PhD, FACB, and Jason Park, MD
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Now days most laboratories are struggling with a new financial sink, the spiraling volume and exponentially spiraling costs of send out testing. A large majority of that growth can be directly attributed to new Molecular Diagnostic tests. In 2009, the molecular diagnostics industry grew 35%. Te...(Read More)
Posted at 1/18/2011 9:20 AM | Tags: Management/Medical Informatics | Molecular Pathology and Genetics