The Connectivity Gap: Interfacing LC-MS and Automating Data Review

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The Program
Interfacing mass spectrometry (MS) tools with your laboratory information system (LIS) for electronic order and result transmission can be so challenging that it may be a disincentive for clinical laboratories interested in using MS. This presentation will walk attendees through the basics of interface terminology, options currently available from MS vendors, and common obstacles encountered and solutions found during MS interfacing projects.  Once MS data can be transferred electronically, there is great potential for automating MS data review using rules in the LIS, middleware, or third-party software. Examples and best practice considerations for automating MS data review will be discussed.

The Expert
Judy Stone Judith A. (Judy) Stone, PhD, MT (ASCP), DABCC, worked as a CLS in San Jose, CA, and then obtained her doctorate at the University of Toronto.  She served a fellowship in Clinical Chemistry was at the University of Minnesota Hospital.  She has since served as Assistant Professor and Associate Director of Clinical Chemistry at the University of Connecticut Health Center, and as Assistant Professor and Director of the Core, Immunology and Toxicology Laboratories at the University of Massachusetts Medical Center.

Dr. Stone has worked with mass spectrometry tools at Specialty Laboratories, San Francisco General Hospital and Kaiser Regional Laboratories in Northern California.  She is currently Senior CLS Specialist in the Clinical Mass Spectrometry Laboratory, Center for Advanced Laboratory Medicine, at the University of California San Diego.  Her research interest is in mass spectrometry applications and automation for clinical toxicology and endocrinology.

She was the coordinator and provided content for the AACC Online Certificate program "Using Mass Spectrometry in the Clinical Laboratory."  Dr. Stone has been a member of AACC since 1984, serving several local sections, the TDM/Toxicology Division, and national AACC committees.

DISCLOSURE: Dr. Stone has disclosed that neither she nor any member of her immediate family has a financial relationship with a company as defined in the AACC policy on disclosure of potential bias or conflict of interest.

Learning Objectives
After listening to this webinar attendees will be able to:

  1. Distinguish between the different modes of connectivity, file formatting, and message protocols typically used for mass spectrometry interfaces (TCP/IP, .txt, .xml, HL7) versus those more commonly used for automated chemistry analyzers (RS232, ASTM).
  2. List the generic steps needed to interface a mass spectrometer to an LIS.
  3. Describe two common mistakes made when writing and testing rules for the automation of MS data analysis - and how to avoid them.

Target Audience
This conference is intended for laboratory administrators, directors, and managers; pathologists; clinicians; and laboratory IT specialists involved in the integration of mass spec tools and laboratory information systems.

System Requirements
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This program is made possible by an educational grant from Waters Corporation.


For fifty years, Waters Corp. has developed innovative analytical science solutions to support customer discoveries, operations, performance, and regulatory compliance. Their mission is to create business advantages for laboratory-dependent organizations by delivering practical and sustainable scientific innovation to enable advancement in healthcare delivery, environmental management, food safety, and water quality.