American Association for Clinical Chemistry
Better health through laboratory medicine
Cutting Edge Webcasts – Therapeutic Drug Monitoring (TDM) and Toxicology
Cutting Edge Technologies Webcast Series
Program Available from July 1, 2013 through March 31, 2017
 

Intended Audience
This program is intended for clinical pathologists; clinical laboratory physicians, administrators, directors and managers; clinical TDM and toxicology specialists; in vitro diagnostic industry professionals; and others involved in laboratory testing for therapeutic drug monitoring and toxicology analysis.

 

The Lab's Role in Pain Management (originally presented on April 9, 2013)
Catherine Hammett-Stabler, PhD, Professor, Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC

Dr. Hammett-Stabler discusses the issues pain clinics face when caring for patients, the drugs prescribed to pain clinic clients, and the services laboratories can provide to help these clinics provide good patient care.

 

Optimizing LC-MS/MS for TDM of Immunosuppressants (originally presented on May 14, 2013)
James Ritchie, PhD, DABCC, FACB Professor, Pathology and Laboratory Medicine, Emory University School of Medicine, Associate Director, Core and Toxicology Laboratories, Emory University Hospital, and Director, Core Laboratory, Emory Crawford Long Hospital, Atlanta, GA

In hospitals that perform transplants or monitor transplant patients on immunosuppressant drugs, there is a critical need for timely and consistent therapeutic drug monitoring. In response, more labs are turning to LC-MS/MS, selecting this technology as an alternative to immunoassay platforms for analyzing immunosuppressant concentrations in transplant patients. Dr. James Ritchie will present the advantages and disadvantages of using mass spectrometry versus immunoassay for monitoring the use and effectiveness of immunosuppressant drugs.

 

Toxicological Testing in the Clinical Lab: Balancing Current Needs, Clinical Expectations and Reality (originally presented on June 11, 2013)
Robert Middleberg, PhD, Vice President, Quality Assurance, Laboratory Director, and Forensic Toxicologist, NMS Labs, Willow Grove, PA

For bath salts and many other synthetic drugs, labs must give thought to a number of factors—including available testing platforms, staff skill sets, time, test utility, and method validation—to decide if, and when, to develop a test. Dr. Middleburg, a forensic toxicologist, will advise on how labs can manage requests for tests to detect the use of emerging synthetic drugs, as well as strategies to meet clinical needs for testing poisoned patients and patients who are suspected of using or abusing drugs.

Learning Outcomes

The Lab’s Role in Pain Management
After viewing this presentation, you should be able to:

  • Analyze the testing needs of the pain clinic and how they differ from other aspects of toxicology testing
  • Explain the advantages and limitations of using urine toxicology screening in the pain clinic setting
  • Support the pain clinic by providing testing, consultative services and education

Optimizing LC-MS/MS for TDM of Immunosuppressants
After viewing this presentation, you should be able to:

  • Explain the advantages and disadvantages of using LC-MS/MS versus immunoassay for clinical measurement of immunosuppressant drugs.
  • Develop a plan to implement the latest standardization practices of mass spectrometry-based assays for immunosuppressants such as cyclosporine, tacrolimus, and rapamycin.
  • Describe how LC-MS/MS is being used for monitoring newer drugs such as everolimus.

Toxicological Testing in the Clinical Lab: Balancing Current Needs, Clinical Expectations and Reality
After viewing this presentation, you should be able to:

  • Explain the advances in toxicological testing that can help labs keep up with evolving trends in substance abuse.
  • Develop protocols for determining if and when to develop a test for new and structurally unique substances like synthetic cannabinoids.
  • Develop strategies to anticipate and meet the clinical needs for toxicological testing in your institution.

To register for this program, click here.



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