2007 The Edwin F. Ullman Award
Dr. Singh is a research fellow and principal scientist in the assay development group of a Dade Behring facility in Glasgow, Delaware. He has been on the staff of Dade Behring and its predecessor firms since 1984. His research interests include bio-conjugation, protein modification and characterization, and organic synthesis. In the early 1990s, he conceived the use of dendrimers, well-defined nanoscopic synthetic polymers, in controlling the orientation of immobilized immunoreagents for assays requiring very low detection limits and excellent precision. He and his team demonstrated the feasibility of this concept using polyamidoamine dendrimers and showed it was possible to reproducibly achieve highly specific and sensitive assays for important analytes such as creatine kinase MB subunit, thyroxine, and human thyroid-stimulating hormone. This work led to the development of the Stratus CS, an automated clinical analyzer able to analyze six key analytes, including key cardiac markers such as cardiac troponin I and N-terminal pro-brain natriuretic peptide. These and other sensitive assays on the Stratus CS have found great utility in emergency room and critical-care settings, where quick decisions for cardiac and other patients are needed. Dr. Singh is a co-inventor of seven patents relating to clinical diagnostics and a contributing author of a chapter in a book on dendrimers. He has published more than 20 research articles in the fields of clinical and organic chemistry.